The Immune Microenvironment in Clear Cell Renal Cell Carcinoma Dirigée Par Le Pr. Catherine Sautès-fridman Acknowledgments 4

The heterogeneous immune contextures accompanying CD8+ T cell infiltration in clear cell Renal Cell Carcinoma Acknowledgments 2 Acknowledgments My desire to keep my thesis short will be difficult to accomplish in view of all the persons I would like to thank. I would like to thank all the people that had made the last 3 years the biggest and more enriching experience I have had in my life. I shall begin en Español, of course. A mis Papás, a quienes debo todos mi logros. Quienes me enseñaron la importancia del amor, la To Catherine, from the moment we first met, back in December 2011, until the last day of my thesis, I am deeply grateful. For your wonderful dedication, your patience, your strong but always kind advices and criticisms, and must importantly, your desire in helping me grow as a scientist and as a person, as a student and as a potential boss, as a colleague and as a friend, I am deeply grateful. If I could choose again, I would never hesitate to choose you as my boss. To Hervé, for his incredibly wise and always pertinent comments, his restless willing to teach, his inspirational passion for research and knowledge, his fantastic skills in convincing people (including myself) of the importance of research, for all his valuable advices and his quick opera lessons, I am deeply grateful. To the other bosses, thanks to Marie-Caroline for her valuable advices, and her constant disposition in helping me understanding my results. Thanks to Jean-Luc for his kindness, all the valuable discussion, his willing to teach and for his complete support. Thank you Isabelle for your advices, your eagerness and your support. To Lubka, thank you for all your support, your openness and all the interesting discussions. To Sophie Siberil, I write this before going to NY with you, but I'm pretty sure we will have an amazing time there; thanks for being so accessible and opened, for your valuable advices and nourishing discussionsv. thank you for taking the time to read this manuscript and giving constructive criticism. Acknowledgments 3 To Etienne, for his support, his restless willing to help, his not-being-afraid-of-speaking-English, his peacefulness, and for making me feel welcome in France, I would like to thank him. were my biggest support during these 3 years in the lab, I am not sure where I would be without you. You were my technical …